TikTok star Addison Rae appears to show off her frightening nude tits while getting dressed in her Halloween costume in the photos below. Of course a TikTok thot like Addison did not stop at displaying her monstrous mammeries, as she continued her Satanic sluttery out in public by flaunting her terrifying tit toppers while ..
TikTok star Addison Rae appears to show off her nude boobs in the recently released topless photos above. Of course being the blasphemously brazen exhibitionist that she is Addison was not done there, as she also vigorously twerks her ass in the video clip above and flaunts her sinfully uncovered body in a bikini while ..
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Stra6 (for all-trans-retinol uptake) mRNA was upregulated in human breast cancer as compared to normal breast tissue and elevated in colorectal cancer, and undetectable in normal colon tissue. HCT116 human colorectal cancer cells that stably over-expressed Stra6 developed substantially larger tumours than parental cells in athymic nude mice. Stra6 over-expression also promoted the oncogenic potential of MCF-7 breast cancer cells. Stra6 was critical for tumour formation by colorectal cancer cells because of stable down-regulation within the human primary adenocarcinoma SW480 cells by means of an shRNA vector, markedly suppressed tumour formation in athymic nude mice . The oncogenic activity of Stra6 was mediated by STAT3, which is a known driver of cancer . A high-fat diet is associated with 80% of cases of colorectal cancer, and the Stra6-RBP4 pathway plays a role because a high-fat diet increases the level of Stra6 .
RARγ is also an oncogene for human cholangiocarcinoma, clear cell renal cell carcinoma, colorectal cancer, and pancreatic ductal adenocarcinoma. RARγ over-expression in cholangiocarcinoma is associated with resistance to 5-fluorouracil and a poor prognosis. For the human cholangiocarcinoma cell lines QBC939, SK-ChA-1, and MZ-ChA-1, siRNA knockdown of RARγ expression suppressed cell proliferation, and xenograft tumour growth in nude mice was reduced for stably transfected QBC939 cells . Around half of the patients with clear cell renal cell carcinoma were observed to over-express RARγ, as seen from qPCR and a bioinformatics analysis . RARγ mRNA and protein were frequently overexpressed in human colorectal cancer tissue as compared to non-tumourous colorectal tissue, and expression was increased in the cell lines HT29, HCT116, RKO and SW480 as compared to the normal colonic epithelial cells HCoEpiC. Knockdown of RARγ within the cell lines decreased expression of the multidrug resistance 1 protein and increased the sensitivity of the cell lines to 5-fluorouracil, oxaliplatin, and vincristine . The levels of RARγ transcripts were significantly higher in pancreatic ductal adenocarcinoma tissue and high-grade precancerous lesions than in normal pancreatic tissue. Blocking of RARγ signalling via siRNA suppressed the cell proliferation of the pancreatic ductal adenocarcinoma cell lines PK-1 and Panc-1, arresting cells in G1 of the cell cycle without causing apoptosis. Treatment of five lumen-forming patient-derived pancreatic ductal adenocarcinoma organoids with siRNA revealed that RARγ signalling underlies their proliferation by promoting cell cycle progression .
Silybin (HY-13748) is a mixture of flavonolignan and flavonoid polyphenolic compounds extracted from milk thistle seeds. The compounds have anticancer properties, and silybin suppressed the proliferation, migration, and invasive capacity of prostate cancer DU145 cell line cells in in vitro experiments. Silybin also reduced the volume and weight of tumours when prostate cancer cells were implanted into nude mice. These actions were attributed to the downregulation of ALDH1 mRNA and protein expression and inhibition of the activation of RARα . There is gene amplification of ALDH1A1, ALDH1A3, or ALDH3A1 or upregulation of mRNA in 31% of non-small cell lung cancers. DIMATE, an irreversible inhibitor of ALDH1A1 and ALDH1A3, was cytotoxic for non-small cell lung cancer cell lines and effective against orthotopic xenografts and enhanced cisplatin chemotherapy. Hydroxynonenal-protein adduct accumulation, the glutathione S-transferase omega 1-mediated depletion of glutathione, and increased H2O2 led to cell death in orthotopic xenografts . ALDH1A1 expression has been associated with poor differentiation of human colorectal cancer cells and poor patient survival . DEAB inhibition of ALDH1 isoforms sensitised the colorectal cancer cell lines HT-29/eGFP, HCT-116/eGFP, and LS-180/eGFP to chemotherapy. Inhibition of expression of ALD1A1 or ALDH1A3 by siRNA sensitised these cells to capecitabine and 5-FU and inhibited the proliferation of HT-29/eGFP cells in a subcutaneous xenograft model . 041b061a72